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Navigating Perimenopause

A Conversation with Courtney Holmes (DNP, APRN) of Milford Med Spa

Understanding Perimenopause

What is perimenopause, and how does it differ from menopause?
Menopause occurs when someone has gone a full year without a period, signaling an end to ovulation due to insufficient hormone production. Perimenopause is the transition leading up to menopause, often lasting ten or more years, marked by fluctuating progesterone, testosterone, and estrogen levels, causing irregular cycles and various symptoms.

At what age do women typically begin experiencing perimenopause?
Symptoms can begin in the 30s, contrary to the common belief that they start in the 40s or 50s. The timing varies based on genetics and lifestyle. If a woman’s mother or grandmother experienced early or late menopause, she may follow a similar pattern.

What are the most common symptoms?
Initial symptoms include insomnia, anxiety, and hair texture changes due to progesterone decline. Testosterone reduction can cause fatigue and brain fog. Estrogen fluctuations lead to irregular periods, hot flashes, night sweats, mood swings, and weight gain.

In my own personal experience, I stopped sleeping well and experienced an uncharacteristic increase in anxiety for the first time in my mid thirties. I wish someone had told me earlier that I could treat these symptoms with progesterone and testosterone, so I could have avoided a decade of unnecessary suffering.

How do hormonal changes impact physical and mental health?
Perimenopause affects the entire body and mind. Fatigue and depression can reduce participation in activities once enjoyed. Sleep disturbances from night sweats can lead to brain fog, affecting job performance. Many women worry about cognitive decline, only to find that hormonal balance improves their mental clarity.

What are lesser-known symptoms?
Rapid heartbeat, depression, anxiety, frozen shoulder, UTIs, and worsened ADHD symptoms can all be linked to perimenopause. Many women undergo unnecessary cardiac testing or receive antidepressants that don’t alleviate symptoms. Hormonal balancing often provides relief.

Common Misconceptions and Diagnosis

What are some misconceptions about perimenopause?
Many believe estrogen replacement alone is the answer, but testosterone and progesterone are often more effective. Patients frequently come to me confused as to why an estrogen patch hasn’t helped, only to find they have estrogen dominance requiring progesterone. Estrogen is typically unnecessary until full menopause, which I confirm through lab monitoring.

How can women differentiate perimenopausal symptoms from other conditions?
A specialized healthcare provider can determine whether symptoms are hormone-related or stem from other medical conditions. Comprehensive lab evaluations, symptom assessments, and medical history reviews are essential. In my practice, I often identify underlying conditions requiring specialist referrals.

Treatment and Management

What treatments help manage perimenopausal symptoms?
Bioidentical hormone replacement therapy (BHRT) effectively improves symptoms and quality of life. This includes prescription progesterone, estradiol, and testosterone, available as capsules, injections, patches, creams, or pellets. Vaginal estradiol cream helps with genitourinary symptoms without affecting the entire body. Other options include antidepressants and psychotherapy.

Are there natural or lifestyle remedies?
Yes. A high-protein, calcium-rich diet with fresh fruits and vegetables helps combat insulin resistance, muscle and bone loss, and weight gain. Women need 0.44-0.55 grams of protein per pound of body weight. Strength training is also beneficial for bone and muscle health.

Preventative and Long-Term Health Considerations

How can women prepare for perimenopause?
Educating oneself before perimenopause helps in making informed healthcare decisions. Recommended books include:

  • The New Menopause by Dr. Mary Claire Haver

  • Estrogen Matters by Avrum Bluming and Carol Tavris

  • The Menopause Brain by Dr. Lisa Mosconi

What long-term health risks should women be aware of?
Hormonal decline increases the risk of Alzheimer’s, osteoporosis, breast cancer, diabetes, and cardiovascular disease. Testosterone and estrogen help prevent osteoporosis. Progesterone is protective against breast cancer. Insulin resistance rises with estrogen decline, raising the risk of diabetes.

Support and Advocacy

What advice do you have for women who feel unsupported or misunderstood?
Advocate for yourself and find a medical provider who will listen and provide proactive treatments and advice. Support groups are wonderful for sharing ideas and connecting with others going through similar experiences so you don’t feel alone. We have a monthly support group that women are welcome to attend, led by our menopause certified coach. 

How can healthcare providers better support women experiencing perimenopause?
Providers must seek continued education on perimenopause. Many women on estrogen alone without progesterone experience estrogen dominance, leading to weight gain, mood swings, and breast tenderness. Proper hormone balancing is key to improving quality of life.

"Symptoms can begin in the 30s, contrary to the common belief that they start in the 40s or 50s."

"Advocate for yourself and find a medical provider who will listen and provide proactive treatments and advice. Support groups are wonderful for sharing ideas and connecting with others going through similar experiences."